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[药物转运体的研究方法]

[Methods for the study of drug transporters].

作者信息

Li Dan, Sheng Li, Li Yan

出版信息

Yao Xue Xue Bao. 2014 Jul;49(7):963-70.

Abstract

As a functional membrane protein, drug transporters play an important role in the absorption, distribution, metabolism and excretion of drugs. The functional omission or inhibition of drug transporters is believed to be involved in the drug-drug interaction and pathogenesis of certain diseases. Understanding the function of drug transporters is highly significant in terms of pharmacokinetics, pharmacodynamics and toxicity of drugs. This article summarized the methods for the study of drug transporters in vitro and in vivo.

摘要

作为一种功能性膜蛋白,药物转运体在药物的吸收、分布、代谢和排泄过程中发挥着重要作用。药物转运体的功能缺失或抑制被认为与药物相互作用及某些疾病的发病机制有关。了解药物转运体的功能在药物的药代动力学、药效学和毒性方面具有重要意义。本文总结了体外和体内研究药物转运体的方法。

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