Saito Takafumi, Tomita Kyoko, Haga Hiroaki, Okumoto Kazuo, Ueno Yoshiyuki
Takafumi Saito, Kyoko Tomita, Hiroaki Haga, Kazuo Okumoto, Yoshiyuki Ueno, Department of Gastroenterology, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
World J Methodol. 2013 Dec 26;3(4):65-9. doi: 10.5662/wjm.v3.i4.65.
Bone marrow cells are capable of differentiation into liver cells. Therefore, transplantation of bone marrow cells has considerable potential as a future therapy for regeneration of damaged liver tissue. Autologous bone marrow infusion therapy has been applied to patients with liver cirrhosis, and improvement of liver function parameters has been demonstrated. In this review, we summarize clinical trials of regenerative therapy using bone marrow cells for advanced liver diseases including cirrhosis, as well as topics pertaining to basic in vitro or in vivo approaches in order to outline the essentials of this novel treatment modality.
骨髓细胞能够分化为肝细胞。因此,骨髓细胞移植作为未来受损肝组织再生治疗方法具有巨大潜力。自体骨髓输注疗法已应用于肝硬化患者,并已证明肝功能参数有所改善。在本综述中,我们总结了使用骨髓细胞治疗包括肝硬化在内的晚期肝病的再生疗法的临床试验,以及与体外或体内基础研究方法相关的主题,以概述这种新型治疗方式的要点。