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益生菌在炎症性肠病和肠易激综合征中的应用。

The use of probiotics in IBD and IBS.

作者信息

De Greef E, Vandenplas Y, Hauser B, Devreker T, Veereman G

机构信息

Pediatric Gastroenterology UZ Brussel, Belgium -

出版信息

Minerva Pediatr. 2014 Oct;66(5):491-500. Epub 2014 Sep 22.

Abstract

While the role of microflora is well established in the development of inflammatory bowel disease (IBS); data is still emerging regarding IBS as the knowledge on brain-gut interaction grows. For both patient groups multiple efficacious treatments exist, but there are still unmet needs as long term disease control remains an issue. Given the importance of the microbiome on the development of the immune system and the interaction between the microbiome and the host organism, this "route" is being examined increasingly as a therapeutic possibility in both pathologies with variable results. We here provide a short overview on the existing data, meta-analysis and single studies, on probiotic treatment in both diseases.

摘要

虽然微生物群在炎症性肠病(IBS)的发展中所起的作用已得到充分证实;但随着脑-肠相互作用知识的不断增长,关于IBS的数据仍在不断涌现。对于这两类患者群体,都有多种有效的治疗方法,但由于长期疾病控制仍然是一个问题,所以仍存在未满足的需求。鉴于微生物群对免疫系统发育的重要性以及微生物群与宿主生物体之间的相互作用,在这两种疾病中,作为一种治疗可能性,这条“途径”正受到越来越多的研究,不过结果各不相同。我们在此简要概述关于这两种疾病益生菌治疗的现有数据、荟萃分析和单项研究。

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