[2014年脉冲式促性腺激素释放激素疗法诱导排卵：文献综述与当前实践总结]
[Ovulation induction by pulsatile GnRH therapy in 2014: literature review and synthesis of current practice].
作者信息
Gronier H, Peigné M, Catteau-Jonard S, Dewailly D, Robin G
机构信息
Service de gynécologie-obstétrique et médecine de la reproduction, centre hospitalier inter-communal de Poissy St-Germain, 10, rue Champ-Gaillard, 78303 Poissy cedex, France.
Service de gynécologie endocrinienne et médecine de la reproduction, centre hospitalier régional universitaire de Lille, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
出版信息
Gynecol Obstet Fertil. 2014 Oct;42(10):732-40. doi: 10.1016/j.gyobfe.2014.07.017. Epub 2014 Sep 22.
The hypogonadotropic hypogonadism is an easily treatable form of female infertility. The most common cause of hypogonadotropic hypogonadism is functional hypothalamic amenorrhea. The GnRH pump is a simple and effective treatment to restore fertility of patients with hypothalamic amenorrhea: cumulative pregnancy rate is estimated between 70 and 100% after 6 cycles, compared to a low rate of complications and multiple pregnancies. While only 2.8 cycles are on average required to achieve a pregnancy with a pump, this induction of ovulation stays underused in France. The objective of this paper is to propose a practical manual of pulsatile GnRH, in order to improve the accessibility of pulsatile GnRH for patients with hypogonadotropic hypogonadism.
低促性腺激素性性腺功能减退是女性不孕症中一种易于治疗的类型。低促性腺激素性性腺功能减退最常见的原因是功能性下丘脑闭经。GnRH泵是恢复下丘脑闭经患者生育能力的一种简单有效的治疗方法：6个周期后累积妊娠率估计在70%至100%之间，并发症和多胎妊娠率较低。虽然使用泵平均只需2.8个周期就能实现妊娠，但在法国这种促排卵方法的应用仍未得到充分利用。本文的目的是提出一份GnRH脉冲治疗实用手册，以提高低促性腺激素性性腺功能减退患者获得GnRH脉冲治疗的机会。
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