Cho In-Jeong, Chang Hyuk-Jae, Hong Geu-Ru, Heo Ran, Sung Ji Min, Lee Sang-Eun, Chang Byung-Chul, Shim Chi Young, Ha Jong-Won, Chung Namsik
Division of Cardiology, Severance Cardiovascular Hospital, Seoul, Korea.
Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
Echocardiography. 2015 Jun;32(6):896-903. doi: 10.1111/echo.12756. Epub 2014 Sep 24.
This study aimed to explore whether echocardiographic measurements during the early postoperative period can predict persistent left ventricular systolic dysfunction (LVSD) after aortic valve surgery in patients with chronic aortic regurgitation (AR).
We prospectively recruited 54 patients (59 ± 12 years) with isolated chronic severe AR who subsequently underwent aortic valve surgery. Standard transthoracic echocardiography was performed before the operation, during the early postoperative period (≤2 weeks), and then 1 year after the surgery.
Twelve patients with preoperative LVSD demonstrated LVSD at early after the surgery. Of the 42 patients without LVSD at preoperative echocardiography, 15 patients (36%) developed early postoperative LVSD after surgical correction. All 27 patients without LVSD at early postoperative echocardiography maintained LV function at 1 year after surgery. In the other 27 patients with postoperative LVSD, 17 patients recovered from LVSD and 10 patients did not at 1 year after surgery. Multiple logistic analysis demonstrated that postoperative left atrial volume index (LAVI) was the only independent predictor for persistent LVSD at 1 year after surgery in patients with postoperative LVSD (OR 1.180, 95% CI, 1.003-1.390, P = 0.046). The optimal LAVI cutoff value (>34.9 mL/m(2) ) had a sensitivity of 80% and a specificity of 88% for the prediction of persistent LVSD.
Prevalence of early postoperative LVSD was relatively high, even in the patients without LVSD at preoperative echocardiography. Postoperative LAVI could be useful to predict persistent LVSD after aortic valve surgery in patients with early postoperative LVSD.
本研究旨在探讨在慢性主动脉瓣反流(AR)患者主动脉瓣手术后早期进行的超声心动图测量是否能够预测持续性左心室收缩功能障碍(LVSD)。
我们前瞻性招募了54例(59±12岁)孤立性慢性重度AR患者,这些患者随后接受了主动脉瓣手术。在手术前、术后早期(≤2周)以及术后1年进行标准经胸超声心动图检查。
12例术前存在LVSD的患者术后早期仍表现为LVSD。在术前超声心动图检查无LVSD的42例患者中,15例(36%)在手术矫正后出现术后早期LVSD。术后早期超声心动图检查无LVSD的所有27例患者在术后1年维持左心室功能。在其他27例术后出现LVSD的患者中,17例患者术后1年从LVSD中恢复,10例未恢复。多因素逻辑分析表明,术后左心房容积指数(LAVI)是术后出现LVSD患者术后1年持续性LVSD的唯一独立预测因素(OR 1.180,95%CI,1.003 - 1.390,P = 0.046)。预测持续性LVSD的最佳LAVI临界值(>34.9 mL/m²)的敏感性为80%,特异性为88%。
即使术前超声心动图检查无LVSD的患者,术后早期LVSD的发生率也相对较高。术后LAVI可能有助于预测术后早期出现LVSD的患者主动脉瓣手术后的持续性LVSD。