脑钠肽（BNP）对自发性高血压大鼠的利钠和降压作用

Natriuretic and hypotensive effects of brain natriuretic peptide (BNP) in spontaneously hypertensive rats.

作者信息

Kita T, Kida O, Kato J, Nakamura S, Eto T, Minamino N, Kangawa K, Matsuo H, Tanaka K

机构信息

First Department of Internal Medicine, Miyazaki Medical College, Japan.

出版信息

Life Sci. 1989;44(21):1541-5. doi: 10.1016/0024-3205(89)90447-5.

DOI:10.1016/0024-3205(89)90447-5

PMID:2525217

Abstract

Effects of four doses (0.1, 0.2, 1.0 and 2.0 nmol/kg) of brain natriuretic peptide (BNP) on natriuresis and blood pressure were investigated in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). An intravenous injection of 1.0 and 2.0 nmol/kg of BNP caused a significant increase of natriuresis and reduction of blood pressure in SHR and WKY. These effects were essentially identical to the effects of atrial natriuretic peptide (ANP). Remarkable bioactivity elicited by BNP rasises the possibility that BNP has a role in the regulation of blood pressure and water-electrolyte balance. On the other hand, when the effects of BNP on both strains of rats were compared with those of alpha-human ANP reported previously, the hypotensive effect of BNP was less than those of alpha-human ANP only in SHR. It is suggested that BNP might have different bioactivity than that of ANP in SHR.

摘要

在麻醉的自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）中，研究了四种剂量（0.1、0.2、1.0和2.0 nmol/kg）的脑钠肽（BNP）对尿钠排泄和血压的影响。静脉注射1.0和2.0 nmol/kg的BNP可使SHR和WKY的尿钠排泄显著增加，血压降低。这些作用与心钠素（ANP）的作用基本相同。BNP引发的显著生物活性增加了BNP在血压和水电解质平衡调节中起作用的可能性。另一方面，当将BNP对两种大鼠的作用与先前报道的α-人ANP的作用进行比较时，仅在SHR中，BNP的降压作用小于α-人ANP的降压作用。提示BNP在SHR中可能具有与ANP不同的生物活性。