Haughey Anne-Marie, Foucher Caroline, Guilhabert Benoit, Kanibolotsky Alexander L, Skabara Peter J, Burley Glenn, Dawson Martin D, Laurand Nicolas
University of Strathclyde, Institute of Photonics, Glasgow, UK.
Faraday Discuss. 2014;174:369-81. doi: 10.1039/c4fd00091a. Epub 2014 Sep 25.
Bio-functionalised luminescent organic semiconductors are attractive for biophotonics because they can act as efficient laser materials while simultaneously interacting with molecules. In this paper, we present and discuss a laser biosensor platform that utilises a gain layer made of such an organic semiconductor material. The simple structure of the sensor and its operation principle are described. Nanolayer detection is shown experimentally and analysed theoretically in order to assess the potential and the limits of the biosensor. The advantage conferred by the organic semiconductor is explained, and comparisons to laser sensors using alternative dye-doped materials are made. Specific biomolecular sensing is demonstrated, and routes to functionalisation with nucleic acid probes, and future developments opened up by this achievement, are highlighted. Finally, attractive formats for sensing applications are mentioned, as well as colloidal quantum dots, which in the future could be used in conjunction with organic semiconductors.
生物功能化发光有机半导体因其可作为高效激光材料同时与分子相互作用而在生物光子学领域颇具吸引力。在本文中，我们展示并讨论了一种利用由这种有机半导体材料制成的增益层的激光生物传感器平台。描述了该传感器的简单结构及其工作原理。通过实验展示并从理论上分析了纳米层检测，以评估生物传感器的潜力和局限性。解释了有机半导体所赋予的优势，并与使用替代染料掺杂材料的激光传感器进行了比较。展示了特定生物分子传感，强调了用核酸探针进行功能化的途径以及这一成果所开启的未来发展方向。最后，提及了传感应用的有吸引力的形式以及胶体量子点，未来它们可与有机半导体结合使用。
