Keskin Ugur, Ercan Cihangir Mutlu, Yilmaz Ali, Babacan Ali, Korkmaz Cem, Duru Namik Kemal, Ergun Ali
J Pak Med Assoc. 2014 Jul;64(7):830-2.
The aim of this case series was to describe our experience with random-start controlled ovarian hyperstimulation (RS-COH) with the use of letrozole for fertility preservation. GnRH antagonist and letrozole cycles were started in three patients with a diagnosis of cancer and had a limited time window for fertility preservation for COH before initiating cancer therapy. Cycles were started in the late follicular or luteal phase, and the duration of COH ranged between 7-8 days. A total of 4-14 oocytes were retrieved, the peak E2 levels were 252-354 pg/ml and the saved time for start of the cancer treatment were 16-26 days for each patient. In conclusion, RS-COH with letrozole cycle is a reasonable option for fertility preservation in cancer patients for whom the treatment window may be narrow. Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.
本病例系列的目的是描述我们使用来曲唑进行随机启动控制性卵巢刺激（RS-COH）以保存生育力的经验。三名被诊断患有癌症且在开始癌症治疗前进行控制性卵巢刺激（COH）以保存生育力的时间窗口有限的患者开始了促性腺激素释放激素（GnRH）拮抗剂和来曲唑周期。周期在卵泡晚期或黄体期开始，COH的持续时间为7至8天。每位患者共取卵4至14个，雌二醇（E2）峰值水平为252至354 pg/ml，开始癌症治疗节省的时间为16至26天。总之，对于治疗窗口可能较窄的癌症患者，来曲唑周期的RS-COH是一种合理的生育力保存选择。此外，使用来曲唑进行COH可能会降低卵巢过度刺激综合征的潜在风险。
