Hunt G E, Johnson G F, Caterson I D
Department of Psychiatry, University of Sydney, NSW, Australia.
J Affect Disord. 1989 Jul-Aug;17(1):21-32. doi: 10.1016/0165-0327(89)90020-7.
The aim of this study was to identify any relationships between various patient factors such as age, gender and concurrent medication that may affect plasma cortisol or dexamethasone (DEX) concentrations. Multiple regression analysis was used to formulate an equation to predict plasma DEX levels to identify factors that may influence DEX bioavailability. Pre- and post-DST cortisol levels did not increase with age, but DEX levels were higher in elderly depressed patients. Neither gender nor psychotropic medication affected plasma cortisol or DEX levels. There was no indication that pre-DST cortisol levels influenced plasma DEX levels to account for the lower DEX values in non-suppressors. Age was the only significant factor found in this study to influence DEX levels and it could be argued that the dose of DEX should be lowered when administering the DST to elderly patients to reduce plasma DEX variability.
本研究的目的是确定年龄、性别和同时服用的药物等各种患者因素之间可能影响血浆皮质醇或地塞米松（DEX）浓度的任何关系。采用多元回归分析来制定一个预测血浆DEX水平的方程，以确定可能影响DEX生物利用度的因素。地塞米松抑制试验（DST）前后的皮质醇水平并未随年龄增加而升高，但老年抑郁症患者的DEX水平较高。性别和精神药物均未影响血浆皮质醇或DEX水平。没有迹象表明DST前的皮质醇水平会影响血浆DEX水平，从而导致非抑制者的DEX值较低。年龄是本研究中发现的影响DEX水平的唯一显著因素，可以认为在对老年患者进行DST时应降低DEX剂量，以减少血浆DEX的变异性。
