在纤维蛋白或纤维蛋白原存在的情况下，链激酶 - 纤溶酶原复合物向链激酶 - 纤溶酶复合物的转化。

The conversion of streptokinase-plasminogen complex to SK-plasmin complex in the presence of fibrin or fibrinogen.

作者信息

Takada Y, Takada A

机构信息

Department of Physiology, Hamamatsu University, School of Medicine, Shizuoka, Japan.

出版信息

Thromb Res. 1989 Apr 15;54(2):133-9. doi: 10.1016/0049-3848(89)90043-1.

DOI:10.1016/0049-3848(89)90043-1

PMID:2526391

Abstract

When equimolar amounts of Glu-plasminogen (Glu-plg) and streptokinase (SK) were mixed in the presence of S-2251, SK-plg complex was formed and only gradually converted to SK-plasmin complex. When equimolar amounts of Glu-plg and SK were mixed with fibrinogen or fibrin, Glu-plg was converted faster to plasmin suggesting that Glu-plg molecule in the complex was converted to plasmin. It is thus concluded that SK-plg complex is converted to SK-plasmin complex slowly in the absence of fibrin or fibrinogen. When SK-plg-fibrin(ogen) complex was formed, plasminogen moiety was converted to plasmin faster inside a trimolecular complex of SK, plasminogen and fibrin(ogen).

摘要

当在S-2251存在的情况下将等摩尔量的谷氨酸纤溶酶原（Glu-plg）和链激酶（SK）混合时，形成了SK-plg复合物，并且只是逐渐转化为SK-纤溶酶复合物。当将等摩尔量的Glu-plg和SK与纤维蛋白原或纤维蛋白混合时，Glu-plg更快地转化为纤溶酶，这表明复合物中的Glu-plg分子转化为了纤溶酶。因此可以得出结论，在没有纤维蛋白或纤维蛋白原的情况下，SK-plg复合物缓慢地转化为SK-纤溶酶复合物。当形成SK-plg-纤维蛋白（原）复合物时，在SK、纤溶酶原和纤维蛋白（原）的三分子复合物内部，纤溶酶原部分更快地转化为纤溶酶。