Aillard Boris, Robertson Naomi S, Baldwin Adam R, Robins Siobhan, Jamieson Andrew G
Department of Chemistry, University of Leicester, Leicester, LE1 7RH, UK.
Org Biomol Chem. 2014 Nov 21;12(43):8775-82. doi: 10.1039/c4ob01832j.
The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide 'stapling' has been achieved using alkylation of a fluorine-modified Ni(II) Schiff base complex as the key step.
通过将氟修饰的镍（II）席夫碱配合物的烷基化作为关键步骤，实现了肽“订书钉”所需的非天然烯基氨基酸的高效不对称合成。
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