Nanda Subrat Kumar, Jayalakshmi Sita, Mohandas Surath
Department of Neurology, Krishna Institute of Medical Sciences, Secunderabad, Andhra Pradesh, India.
Department of Neurology, Krishna Institute of Medical Sciences, Secunderabad, Andhra Pradesh, India.
Pediatr Neurol. 2014 Oct;51(4):570-2. doi: 10.1016/j.pediatrneurol.2014.06.019. Epub 2014 Jul 1.
Dengue infection is an important arboviral infection in southeast Asia, especially in India. Neurological manifestations of dengue are increasingly recognized.
We report an ischemic stroke due to dengue vasculitis in an 8-year-old child.
We present a girl with a short febrile illness followed by episodic severe headache, with gradually progressive hemiparesis and visual impairment. Her brain magnetic resonance imaging revealed multiple infarctions in the anterior and posterior circulation. The magnetic resonance angiogram revealed irregular narrowing of bilateral middle cerebral arteries, right anterior cerebral artery, left posterior cerebral, and bilateral vertebral arteries suggestive of vasculitis. Her dengue serology was strongly positive for immunoglobulin M with 68.9 panbio units. The rest of the evaluation for pediatric stroke was unremarkable. She was treated with intravenous followed by oral corticosteroids and recovered totally with resolution of vasculitis on magnetic resonance angiogram over the next 3 months.
This child illustrates possible immune-mediated vasculitis caused by dengue infection which is rather a rare presentation in a child who subsequently recovered well. One should consider dengue in childhood strokes in endemic regions.
登革热感染是东南亚尤其是印度一种重要的虫媒病毒感染。登革热的神经学表现越来越受到认可。
我们报告了一名8岁儿童因登革热血管炎导致的缺血性中风。
我们介绍了一名女童,先是有短暂的发热性疾病,随后出现发作性严重头痛,并伴有逐渐进展的偏瘫和视力障碍。她的脑部磁共振成像显示前循环和后循环有多处梗死。磁共振血管造影显示双侧大脑中动脉、右侧大脑前动脉、左侧大脑后动脉及双侧椎动脉不规则狭窄,提示血管炎。她的登革热血清学检测显示免疫球蛋白M呈强阳性,为68.9泛生物单位。小儿中风的其他评估结果无异常。她接受了静脉注射,随后口服皮质类固醇治疗,在接下来的3个月里,磁共振血管造影显示血管炎消退,她完全康复。
这名儿童说明了登革热感染可能引起免疫介导的血管炎,这在儿童中是一种相当罕见的表现,不过该患儿随后恢复良好。在流行地区的儿童中风病例中应考虑登革热。