[一例老年2型糖尿病患者低血糖症的罕见病例：恶性转移性胰岛素瘤]

[A rare case of hypoglycemia in an elderly patient with type 2 diabetes mellitus: malignant metastasizing insulinoma].

作者信息

Podzolkov V I, Dragomiretskaia N A, Koroleva T V, Kavtaradze N N, Iakovleva H H, Podzolkov A V

出版信息

Klin Med (Mosk). 2014;92(2):65-70.

Abstract

The incidence of insulinoma, an insulin-producing tumour arising from pancreatic beta-cells and responsible for the development of fasting hypoglycemia, in the general population is 1-4 per 1,000,000 yearly, mostly at the age of 25-55 yr. Malignization of this neoplasm occurs in 10-15% of the cases. One third of the tumours produce metastases. The most characteristic clinical manifestation of insulinoma is the Whipple's triad, with episodes of fasting hypoglycemia (below 2.8 mmol/l) correctable by intravenous glucose injection or intake of sugar. The authors report a case of intravital diagnosis of malignant metastasizing insulinoma in a 82 year old woman with type 2 diabetes mellitus. A review of relevant literature is presented.

摘要

胰岛素瘤是一种起源于胰腺β细胞并导致空腹低血糖的产生胰岛素的肿瘤，其在普通人群中的发病率为每年百万分之一至四，发病年龄多在25至55岁。该肿瘤的恶变率为10%至15%。三分之一的肿瘤会发生转移。胰岛素瘤最典型的临床表现是Whipple三联征，即空腹低血糖发作（低于2.8 mmol/L），静脉注射葡萄糖或摄入糖分后可缓解。作者报告了一例82岁2型糖尿病女性患者恶性转移性胰岛素瘤的生前诊断病例，并对相关文献进行了综述。