性别决定基因 SRY 可能与肝癌的不良预后相关，但与性别偏向无关。
Sex-determination gene SRY potentially associates with poor prognosis but not sex bias in hepatocellular carcinoma.
机构信息
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China,
出版信息
Dig Dis Sci. 2015 Feb;60(2):427-35. doi: 10.1007/s10620-014-3377-y. Epub 2014 Oct 2.
BACKGROUND
Gender disparity is well known in hepatocellular carcinoma (HCC). SRY is a critical sex-determination gene involved in embryonic development.
AIM
The potential relevance of SRY to HCC progression was evaluated.
METHODS
SRY expression in HCC cell lines and tissues was evaluated. Invasion and wound healing assays were used to evaluate the role of SRY in HCC cell migration. The prognostic value of SRY for HCC patient survival was evaluated.
RESULTS
SRY was highly expressed in HCC cell lines and tumor tissues. Downregulation of SRY expression decreased migration and invasion potential of HCC cells. High SRY levels correlated with poor HCC patient survival. Additionally, neither spatial position nor expression intensity of SRY was correlated with HCC gender disparity.
CONCLUSIONS
High levels of SRY expression correlated with cancer progression and poor HCC patient survival. However, high SRY levels are not significantly correlated with HCC sex bias.
背景
肝细胞癌（HCC）中存在明显的性别差异。SRY 是一个关键的性别决定基因，参与胚胎发育。
目的
评估 SRY 与 HCC 进展的潜在相关性。
方法
评估 SRY 在 HCC 细胞系和组织中的表达。侵袭和划痕愈合实验用于评估 SRY 在 HCC 细胞迁移中的作用。评估 SRY 对 HCC 患者生存的预后价值。
结果
SRY 在 HCC 细胞系和肿瘤组织中高表达。下调 SRY 表达可降低 HCC 细胞的迁移和侵袭潜能。高 SRY 水平与 HCC 患者不良预后相关。此外，SRY 的空间位置和表达强度均与 HCC 的性别差异无关。
结论
高水平的 SRY 表达与癌症进展和 HCC 患者不良预后相关。然而，高 SRY 水平与 HCC 的性别偏差无显著相关性。
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