Goepfert Paul, Bansal Anju
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, 908, 20th Street South, CCB 328, Birmingham, AL 35294, USA.
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, 845, 19th Street South, BBRB 557, Birmingham, AL 35294, USA.
Infect Dis Clin North Am. 2014 Dec;28(4):615-31. doi: 10.1016/j.idc.2014.08.004. Epub 2014 Oct 5.
Although some success was achieved in recent years in HIV prevention, an effective vaccine remains the means with the most potential of curtailing HIV-1 infections worldwide. Despite multiple failed attempts, a recent HIV vaccine regimen demonstrated modest protection from infection. Although the protective efficacy in this trial was not sufficient to warrant licensure, it spurred renewed optimism in the field and has provided valuable insights for improving future vaccine designs. This review summarizes the pertinent details of vaccine development and discusses ways the field is moving forward to develop a vaccine to prevent HIV infection and disease progression.
尽管近年来在艾滋病毒预防方面取得了一些成功，但有效的疫苗仍然是在全球范围内减少艾滋病毒-1感染最具潜力的手段。尽管多次尝试失败，但最近的一种艾滋病毒疫苗方案显示出对感染有一定程度的保护作用。虽然该试验中的保护效力不足以获批上市，但它激发了该领域新的乐观情绪，并为改进未来疫苗设计提供了宝贵的见解。本综述总结了疫苗研发的相关细节，并讨论了该领域为开发预防艾滋病毒感染和疾病进展的疫苗而向前推进的方式。
