葡萄球菌蛋白A基因。

The gene for staphylococcal protein A.

作者信息

Uhlén M, Lindberg M, Philipson L

机构信息

Department of Biochemistry and Biotechnology. Royal Institute of Technology, S-100 44 Stockholm, Sweden; Department of Microbiology, University of Uppsala, Biomedical Center, Box 581, S-751 23 Uppsala, Sweden.

Department of Microbiology, University of Uppsala, Biomedical Center, Box 581, S-751 23 Uppsala, Sweden.

出版信息

Immunol Today. 1984 Aug;5(8):244-8. doi: 10.1016/0167-5699(84)90098-7.

DOI:10.1016/0167-5699(84)90098-7

PMID:25290147

Abstract

Protein A from Staphylococcus aureus has become an important tool in immunology and molecular biology due to its specific binding to the constant region of immunoglobulins (Igs) from most mammalian species(1). Many qualitative and quantitative techniques have been developed which take advantage of this 'pseudo-immune' reaction(2). In addition, solid state protein A has recently been introduced in medical therapy to decrease the amount of circulating immune complexes in sera(3). In this article Mathias Uhlén, Martin Lindberg and Lennart Philipson describe the structure of the protein A molecule and its gene. They also discuss the possibilities for fusing the protein A gene to other genes.

摘要

金黄色葡萄球菌的A蛋白已成为免疫学和分子生物学中的一种重要工具，因为它能与大多数哺乳动物物种免疫球蛋白（Ig）的恒定区特异性结合(1)。人们开发了许多定性和定量技术来利用这种“假免疫”反应(2)。此外，固态A蛋白最近已被引入医学治疗，以减少血清中循环免疫复合物的数量(3)。在本文中，马蒂亚斯·于伦、马丁·林德伯格和伦纳特·菲利普松描述了A蛋白分子及其基因的结构。他们还讨论了将A蛋白基因与其他基因融合的可能性。