Benjaminsen Sigurd
Psykiatrisk Afdeling Odense - Universitetsfunktion, Sdr. Boulevard 29, 5000 Odense C.
Ugeskr Laeger. 2014 Sep 1;176(36).
A high percentage of patients with borderline personality disorder (BPD) are prescribed psychotropic medications. Recent meta-analyses of randomized controlled trials suggested evidence of effects of antiepileptics on impulsivity and anger and of atypical antipsychotics on cognitive-perceptual symptoms and anger. Antidepressants had no or negligible effect. Total BPD severity was not significantly reduced by pharmacotherapy. Longitudinal studies suggest that BPD tends to improve, but it is not clarified whether long-term pharmacotherapy make the naturalistic recovery occur more rapidly.
边缘型人格障碍(BPD)患者中有很大比例被开具了精神药物。最近对随机对照试验的荟萃分析表明,有证据显示抗癫痫药物对冲动和愤怒有作用,非典型抗精神病药物对认知感知症状和愤怒有作用。抗抑郁药没有效果或效果可忽略不计。药物治疗并未显著降低BPD的总体严重程度。纵向研究表明BPD有改善的趋势,但尚不清楚长期药物治疗是否会使自然恢复更快发生。