回应对“分娩过程中催产素介导的 GABA 抑制减弱了啮齿动物后代自闭症发病机制”一文的评论。
Response to Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring".
机构信息
Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. On leave from Iran University of Medical Sciences, Tehran, Iran.
Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. On leave from Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Science. 2014 Oct 10;346(6206):176. doi: 10.1126/science.1256009.
Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.
班比尼 - 朱尼尔等人质疑我们在两种自闭症啮齿动物模型中的治疗是否对成年期有持久影响。作为回应，我们表明，分娩时布美他尼治疗可减轻成年后代的自闭症行为特征。因此，分娩过程中γ-氨基丁酸（GABA）作用的极性在出生后会产生持久的启动作用。
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