Liu Peng, Tan Shengkui, Xiao Shengjun, Yi Shijiang, Ouyang Lei, Hou Qiaoyan, Xiong Weiming, Lei Xun
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Aug;28(15):1109-12.
To investigate the significance and relationship between the expression of FOXC1 and clinicopathological features, and to explore its correlation with E-cadherin.
Immunohistochemical SP method was used to detected the expression of FOXC1 in nasopharyngeal carcinoma tissues and nasopharyngitis tissues.
(1) Immunoreaction to FOXC1 was mainly located in nucleus of nasopharyngeal carcinoma cells. The positive expression rate of FOXC1 in nasopharyngeal carcinoma tissues was 85.3% (81/95), which was significantly higher than that in nasopharyngitis tissues (59.4%) (P < 0.05). (2) The expression of FOXC1 was not related to patients' age and gender, clinical stage of cancer and lymph node metastasis (P > 0.05). (3) There was a correlation between the expression of FOXC1 and down-regulated expression of E-cadherin in nasopharyngeal carcinoma tissues (P < 0.05).
FOXC1 may play an important role in generation and progression of nasopharyngeal carcinoma, there may be a correlation between the expression of FOXC1 and down-regulated expression of E-cadherin, also FOXC1 may play an important role in the process of EMT in nasopharyngeal carcinoma by regulating E-cadherin.
探讨FOXC1表达与鼻咽癌临床病理特征之间的意义及关系，并探讨其与E-钙黏蛋白的相关性。
采用免疫组织化学SP法检测鼻咽癌组织和鼻咽炎组织中FOXC1的表达。
（1）FOXC1免疫反应主要位于鼻咽癌细胞核。鼻咽癌组织中FOXC1阳性表达率为85.3%（81/95），显著高于鼻咽炎组织（59.4%）（P<0.05）。（2）FOXC1的表达与患者年龄、性别、癌症临床分期及淋巴结转移无关（P>0.05）。（3）鼻咽癌组织中FOXC1的表达与E-钙黏蛋白表达下调相关（P<0.05）。
FOXC1可能在鼻咽癌的发生发展中起重要作用，FOXC1的表达与E-钙黏蛋白表达下调可能存在相关性，且FOXC1可能通过调节E-钙黏蛋白在鼻咽癌上皮-间质转化过程中起重要作用。
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