精神分裂症患者在心理旋转任务中的半球优势。
Hemispheric dominance during the mental rotation task in patients with schizophrenia.
作者信息
Chen Jiu, Yang Laiqi, Zhao Jin, Li Lanlan, Liu Guangxiong, Ma Wentao, Zhang Yan, Wu Xingqu, Deng Zihe, Tuo Ran
机构信息
Center for Mental Disease Control and Prevention, Third Hospital of the People's Liberation Army, Baoji, Shaanxi Province, China.
出版信息
Shanghai Arch Psychiatry. 2012 Apr;24(2):76-82. doi: 10.3969/j.issn.1002-0829.2012.02.002.
BACKGROUND
Mental rotation is a spatial representation conversion capability using an imagined object and either object or self-rotation. This capability is impaired in schizophrenia.
OBJECTIVE
To provide a more detailed assessment of impaired cognitive functioning in schizophrenia by comparing the electrophysiological profiles of patients with schizophrenia and controls while completing a mental rotation task using both normally-oriented images and mirror images.
METHODS
This electroencephalographic study compared error rates, reaction times and the topographic map of event-related potentials in 32 participants with schizophrenia and 29 healthy controls during mental rotation tasks involving both normal images and mirror images.
RESULTS
Among controls the mean error rate and the mean reaction time for normal images and mirror images were not significantly different but in the patient group the mean (sd) error rate was higher for mirror images than for normal images (42% [6%] vs. 32% [9%], t=2.64, p=0.031) and the mean reaction time was longer for mirror images than for normal images (587 [11] ms vs. 571 [18] ms, t=2.83, p=0.028). The amplitude of the P500 component at Pz (parietal area), Cz (central area), P3 (left parietal area) and P4 (right parietal area) were significantly lower in the patient group than in the control group for both normal images and mirror images. In both groups the P500 for both the normal and mirror images was significantly higher in the right parietal area (P4) compared with left parietal area (P3).
CONCLUSION
The mental rotation abilities of patients with schizophrenia for both normally-oriented images and mirror images are impaired. Patients with schizophrenia show a diminished left cerebral contribution to the mental rotation task, a more rapid response time, and a differential response to normal images versus mirror images not seen in healthy controls. Specific topographic characteristics of the EEG during mental rotation tasks are potential biomarkers for schizophrenia.
背景
心理旋转是一种利用想象的物体以及物体或自身旋转进行空间表征转换的能力。这种能力在精神分裂症患者中受损。
目的
通过比较精神分裂症患者和对照组在使用正常方向图像和镜像完成心理旋转任务时的电生理特征，更详细地评估精神分裂症患者受损的认知功能。
方法
这项脑电图研究比较了32名精神分裂症患者和29名健康对照在涉及正常图像和镜像的心理旋转任务中的错误率、反应时间和事件相关电位地形图。
结果
在对照组中，正常图像和镜像的平均错误率和平均反应时间无显著差异，但在患者组中，镜像的平均（标准差）错误率高于正常图像（42% [6%] 对32% [9%]，t = 2.64，p = 0.031），镜像的平均反应时间长于正常图像（587 [11] 毫秒对571 [18] 毫秒，t = 2.83，p = 0.028）。在正常图像和镜像中，患者组在Pz（顶叶区域）、Cz（中央区域）、P3（左顶叶区域）和P4（右顶叶区域）的P500成分波幅均显著低于对照组。在两组中，正常图像和镜像的P500在右顶叶区域（P4）均显著高于左顶叶区域（P3）。
结论
精神分裂症患者对正常方向图像和镜像的心理旋转能力均受损。精神分裂症患者在心理旋转任务中左侧大脑的贡献减少，反应时间更快，对正常图像和镜像的反应与健康对照不同。心理旋转任务期间脑电图的特定地形特征是精神分裂症的潜在生物标志物。
Zotero 插件