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Synthesis aided structural determination of amyloid-β(1-15) glycopeptides, new biomarkers for Alzheimer's disease.淀粉样β（1-15）糖肽的合成辅助结构确定，阿尔茨海默病的新生物标志物。
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Synthetic standard aided quantification and structural characterization of amyloid-beta glycopeptides enriched from cerebrospinal fluid of Alzheimer's disease patients.采用合成标准辅助定量和结构特征分析从阿尔茨海默病患者脑脊液中富集的淀粉样β糖苷肽。
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Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.人脑脊液中淀粉样前体蛋白/淀粉样β肽的苏氨酸、丝氨酸和酪氨酸糖基化的位点特异性特征。
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11848-53. doi: 10.1073/pnas.1102664108. Epub 2011 Jun 28.
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Synthesis, aggregation, and neurotoxicity of the Alzheimer's Abeta1-42 amyloid peptide and its isoaspartyl isomers.阿尔茨海默病β淀粉样蛋白1-42及其异天冬氨酰异构体的合成、聚集和神经毒性
Bioorg Med Chem Lett. 1999 Apr 5;9(7):953-6. doi: 10.1016/s0960-894x(99)00121-3.
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Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra.阿尔茨海默病合成β-淀粉样肽的溶液构象和聚集特性。圆二色光谱分析。
J Mol Biol. 1992 Jun 20;225(4):1075-93. doi: 10.1016/0022-2836(92)90106-t.
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Inhibition of Alzheimer's amyloid-β peptide aggregation and its disruption by a conformationally restricted α/β hybrid peptide.一种构象受限的α/β杂合肽对阿尔茨海默病淀粉样β肽聚集的抑制及其解聚作用。
Chem Commun (Camb). 2015 Feb 11;51(12):2245-8. doi: 10.1039/c4cc09063b.
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Molecular structure of a fibrillar Alzheimer's A beta fragment.一种纤维状阿尔茨海默病β淀粉样蛋白片段的分子结构。
Biochemistry. 2000 Oct 31;39(43):13269-75. doi: 10.1021/bi000637v.
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Successful syntheses of beta amyloid-(25-35)-peptide: a difficult sequence by N-(9-fluorenylmethoxycarbonyl) chemistry.β-淀粉样蛋白（25-35）肽的成功合成：通过N-（9-芴甲氧羰基）化学法合成的困难序列
Biochem Soc Trans. 1994 Nov;22(4):1052-4. doi: 10.1042/bst0221052.
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Coexisting order and disorder within a common 40-residue amyloid-β fibril structure in Alzheimer's disease brain tissue.阿尔茨海默病脑组织中共同的 40 残基淀粉样-β纤维结构内共存的有序和无序。
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Gly25-Ser26 amyloid β-protein structural isomorphs produce distinct Aβ42 conformational dynamics and assembly characteristics.甘氨酸25-丝氨酸26淀粉样β蛋白结构同构体产生不同的Aβ42构象动力学和组装特征。
J Mol Biol. 2014 Jun 26;426(13):2422-41. doi: 10.1016/j.jmb.2014.04.004. Epub 2014 Apr 13.
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Development of a GalNAc-Tyrosine-Specific Monoclonal Antibody and Detection of Tyrosine -GalNAcylation in Numerous Human Tissues and Cell Lines.GalNAc-Tyrosine 特异性单克隆抗体的研制及其在众多人类组织和细胞系中酪氨酸 -GalNAc 化的检测。
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Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis.通过蛋白半合成揭示翻译后修饰对淀粉样蛋白的影响。
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Enhanced Binding and Reduced Immunogenicity of Glycoconjugates Prepared via Solid-State Photoactivation of Aliphatic Diazirine Carbohydrates.通过固态光活化脂族重氮化合物制备糖缀合物，增强结合和降低免疫原性。
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Molecular Recognition in C-Type Lectins: The Cases of DC-SIGN, Langerin, MGL, and L-Sectin.C 型凝集素中的分子识别：以 DC-SIGN、 langerin、MGL 和 L-选择素为例。
Chembiochem. 2020 Nov 2;21(21):2999-3025. doi: 10.1002/cbic.202000238. Epub 2020 Jul 2.
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Three Decades of Amyloid Beta Synthesis: Challenges and Advances.β-淀粉样蛋白合成的三十年：挑战与进展
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Synthetic standard aided quantification and structural characterization of amyloid-beta glycopeptides enriched from cerebrospinal fluid of Alzheimer's disease patients.采用合成标准辅助定量和结构特征分析从阿尔茨海默病患者脑脊液中富集的淀粉样β糖苷肽。
Sci Rep. 2019 Apr 2;9(1):5522. doi: 10.1038/s41598-019-41897-5.
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Rapid phenolic O-glycosylation of small molecules and complex unprotected peptides in aqueous solvent.在水溶剂中快速酚 O-糖基化小分子和复杂未保护的肽。
Nat Chem. 2018 Jun;10(6):644-652. doi: 10.1038/s41557-018-0041-8. Epub 2018 Apr 30.
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GalNAc-Tyrosine Is a Ligand of Plant Lectins, Antibodies, and Human and Murine Macrophage Galactose-Type Lectins.N-乙酰半乳糖胺-酪氨酸是植物凝集素、抗体以及人和小鼠巨噬细胞半乳糖型凝集素的配体。
ACS Chem Biol. 2017 Aug 18;12(8):2172-2182. doi: 10.1021/acschembio.7b00471. Epub 2017 Jul 14.
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Liquid chromatography-tandem mass spectrometry-based fragmentation analysis of glycopeptides.基于液相色谱-串联质谱的糖肽片段分析
Glycoconj J. 2016 Jun;33(3):261-72. doi: 10.1007/s10719-016-9649-3. Epub 2016 Jan 18.
本文引用的文献
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Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.推进阿尔茨海默病研究诊断标准：IWG-2 标准。
Lancet Neurol. 2014 Jun;13(6):614-29. doi: 10.1016/S1474-4422(14)70090-0.
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Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.金属离子在阿尔茨海默病淀粉样β肽自组装中的作用。
Inorg Chem. 2013 Nov 4;52(21):12193-206. doi: 10.1021/ic4003059. Epub 2013 Apr 22.
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2013 Alzheimer's disease facts and figures.2013 年阿尔茨海默病事实和数据。
Alzheimers Dement. 2013 Mar;9(2):208-45. doi: 10.1016/j.jalz.2013.02.003.
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Untangling amyloid-β, tau, and metals in Alzheimer's disease.厘清阿尔茨海默病中的淀粉样β、tau 和金属。
ACS Chem Biol. 2013 May 17;8(5):856-65. doi: 10.1021/cb400080f. Epub 2013 Mar 18.
5
Bioinorganic chemistry of Alzheimer's disease.阿尔茨海默病的生物无机化学
Chem Rev. 2012 Oct 10;112(10):5193-239. doi: 10.1021/cr300009x. Epub 2012 Jul 13.
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Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.人脑脊液中淀粉样前体蛋白/淀粉样β肽的苏氨酸、丝氨酸和酪氨酸糖基化的位点特异性特征。
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11848-53. doi: 10.1073/pnas.1102664108. Epub 2011 Jun 28.
7
Affinity of Cu+ for the copper-binding domain of the amyloid-β peptide of Alzheimer's disease.阿尔茨海默病淀粉样β肽的铜结合域与 Cu+的亲和力。
Inorg Chem. 2011 Mar 7;50(5):1614-8. doi: 10.1021/ic100967s. Epub 2011 Jan 31.
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Protein tyrosine O-glycosylation--a rather unexplored prokaryotic glycosylation system.蛋白酪氨酸 O-糖基化——一个相当未被探索的原核糖基化系统。
Glycobiology. 2010 Jun;20(6):787-98. doi: 10.1093/glycob/cwq035. Epub 2010 Mar 3.
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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease.阿尔茨海默病的脑脊液和血浆生物标志物。
Nat Rev Neurol. 2010 Mar;6(3):131-44. doi: 10.1038/nrneurol.2010.4. Epub 2010 Feb 16.
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Enrichment of glycopeptides for glycan structure and attachment site identification.用于聚糖结构和连接位点鉴定的糖肽富集
Nat Methods. 2009 Nov;6(11):809-11. doi: 10.1038/nmeth.1392. Epub 2009 Oct 18.
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