Maruyama H, Goto K, Sugai N
Masui. 1989 Jul;38(7):868-73.
Effect of pancuronium on the increased afferent discharge of the muscle spindle induced by succinylcholine (SCC) (Succinylcholine induced discharge, SID) was studied in the decerebrate cat by recording the discharge of the muscle nerve going to the gastrocnemius muscle. This action of pancuronium was compared with that of tubocurarine and the antagonistic action if any by neostigmine of this action of pancuronium and tubocurarine was also studied. Pancuronium 0.025 or 0.05mg.kg-1 reduced the peak values of SID to 25.2% and 6.8% of the control value respectively. Tubocurarine 0.125mg.kg-1 reduced this to 38.2%. Inhibition of the SID by pancuronium or tubocurarine was not reversed by the administration of neostigmine. Thus pancuronium reduced SID depending on its dose. The ability of pancuronium and tubocurarine to suppress SID is related to their neuromuscular blocking effects, but the failure by neostigmine to reverse this action of pancuronium or tubocurarine might suggest a different type of reaction at the acetylcholine receptor of the intrafusal fiber compared with the one at the acetylcholine receptor of the skeletal muscle.
在去大脑猫中，通过记录支配腓肠肌的肌肉神经放电，研究了泮库溴铵对琥珀酰胆碱（SCC）诱导的肌梭传入放电增加（琥珀酰胆碱诱导放电，SID）的影响。将泮库溴铵的这种作用与筒箭毒碱的作用进行比较，并研究了新斯的明对泮库溴铵和筒箭毒碱此作用的拮抗作用（如有）。0.025或0.05mg.kg-1的泮库溴铵分别将SID的峰值降低至对照值的25.2%和6.8%。0.125mg.kg-1的筒箭毒碱将其降低至38.2%。给予新斯的明不能逆转泮库溴铵或筒箭毒碱对SID的抑制作用。因此，泮库溴铵根据其剂量降低SID。泮库溴铵和筒箭毒碱抑制SID的能力与其神经肌肉阻滞作用有关，但新斯的明未能逆转泮库溴铵或筒箭毒碱的这种作用，这可能表明与骨骼肌乙酰胆碱受体相比，梭内肌纤维乙酰胆碱受体存在不同类型的反应。
