Teilmann Anne Charlotte, Falkenberg Malene Kari, Hau Jann, Abelson Klas Stig Peter
1] Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. [2].
Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lab Anim (NY). 2014 Nov;43(11):397-403. doi: 10.1038/laban.570.
Vascular catheterization is increasingly carried out in laboratory mice, but the long-term patency of catheters implanted in mice is limited owing to their small size. The authors compared mice that were catheterized in their right common carotid artery either with a silicone catheter with a polyurethane tip or with a 100% polyurethane catheter to determine which catheter type was better suited for long-term studies in mice. The catheters were inspected daily and were flushed if blood was visible in the catheters; if no blood was visible, they were flushed every 3 d. Silicone catheters were patent for a shorter period of time than polyurethane catheters, which were patent for a median of 6 d and up to 25 d. The authors identify the principal causes of catheter failure and discuss how they can be prevented.
血管插管术在实验小鼠中越来越多地被采用，但由于小鼠体型小，植入小鼠体内的导管长期通畅性有限。作者将右侧颈总动脉插入硅胶导管（带有聚氨酯尖端）的小鼠与插入100%聚氨酯导管的小鼠进行比较，以确定哪种导管类型更适合小鼠的长期研究。每天检查导管，如果导管内可见血液则进行冲洗；如果未见血液，则每3天冲洗一次。硅胶导管的通畅时间比聚氨酯导管短，聚氨酯导管的中位通畅时间为6天，最长可达25天。作者确定了导管失败的主要原因，并讨论了如何预防这些原因。
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