Klotz Laura V, Ingrisch Michael, Eichhorn Martin E, Niemoeller Olivier, Siedek Vanessa, Gürkov Robert, Clevert Dirk-Andre
Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, University of Munich, Munich, Germany.
Institut of Clinical Radiology, University of Munich, Munich, Germany.
Clin Hemorheol Microcirc. 2014;58(1):261-9. doi: 10.3233/CH-141895.
Contrast enhanced ultrasound (CE-US) is a promising imaging modality for non-invasive analysis of functional vascularisation. Lesions of the parotid gland are associated with a vascularisation that differs from normal gland tissue. The aim of this clinical study was to further analyse the perfusion in parotid gland lesions with CE-US. The new quantification software VueBox (Bracco, Italy) was used to assess the perfusion, based on DICOM datasets of CE-US examination.
CE-US measurements were performed by intravenous application of a contrast agent (SonoVue, Bracco, Italy) before surgical tumor resection. From the analysis of a time sequence of 2D DICOM contrast images, area under time intensity curve (AUC), peak enhancement (PE), wash-in-rate (WiR) and wash-in-perfusion-index (WiPI) were calculated using VueBox. These were correlated with the histological analyses of the tumor tissue.
Significant difference of area below intensity time curve (AUC), peak enhancement (PE), wash-in-rate (WiR) and wash-in perfusion index (WiPI) were observed in the malign lesions compared to benign tumors (p < 0,05) and in pleomorphic adenoma compared to cystadenolymphoma (p < 0,05).
CE-US seems to be a quantitative and independent method for discriminating between malign and benign parotid gland tumors.
超声造影（CE-US）是一种很有前景的成像方式，可用于对功能性血管生成进行无创分析。腮腺病变的血管生成与正常腺体组织不同。本临床研究的目的是利用CE-US进一步分析腮腺病变的灌注情况。基于CE-US检查的DICOM数据集，使用新型定量软件VueBox（意大利百胜公司）评估灌注情况。
在手术切除肿瘤前，通过静脉注射造影剂（声诺维，意大利百胜公司）进行CE-US测量。通过分析二维DICOM造影图像的时间序列，使用VueBox计算时间强度曲线下面积（AUC）、峰值增强（PE）、流入率（WiR）和流入灌注指数（WiPI）。将这些参数与肿瘤组织的组织学分析结果进行关联。
与良性肿瘤相比，恶性病变的强度时间曲线下面积（AUC）、峰值增强（PE）、流入率（WiR）和流入灌注指数（WiPI）存在显著差异（p < 0.05）；与腺淋巴瘤相比，多形性腺瘤的上述参数也存在显著差异（p < 0.05）。
CE-US似乎是一种区分腮腺良恶性肿瘤的定量且独立的方法。
