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[棘球蚴病外科治疗的改进]

[Improvement of surgical treatment of echinococcosis].

出版信息

Georgian Med News. 2014 Sep(234):11-9.

Abstract

A hydatid disease is a serious public health problem in Kazakhstan. Surgical treatment is the main treatment of hepatic echinococcosis. Considering high rate of recurrence of the disease the search for new methods of surgical treatment remains relevant. The aim of the study was to improve the efficiency and safety of surgical treatment of hepatic echinococcosis; to develop a new physical method for cleaning residual cyst cavity. Experimental and clinical investigation of IED effects on hydadtid cyst embryonic element was studied. In order to monitor the effectiveness of developed method the morphological study of histological material was done. В It is experimentally proved that the optimal mode of impact of IED on germinal elements of hydatid cysts at which their complete destruction, is the exposure 120 seconds by 200 ml of liquid or 0,6 seconds per 1 ml volume. The method of cleaning of residual cavity with IED was developed. By this method for the years 2007-2013, 25 patients were operated on, of which there were 13 (52,0%) men, 12 (48,0%) women. The mean age was 37,8В±0,8. Single cysts observed in 16 (64.0 %) cases, multiple in 9 (36.0%). Primary cysts were observed in 20 (80.0%) cases, recurrent 5 (20.0%). Size up to 10 cm cyst verified in 8 (32.0%) cases, from 10cm to 20 cm in 15 (60.0 %) cases, 20 cm or more - 2 ( 8.0%). To localize the left lobe of the liver was struck in 24.0% of cases, the right to 76.0%. The cysts were located in the right lobe of the liver in 76,0%, left lobe in 24,0%. Echinococcectomy was performed in 22 (53.0%) patients, resection-2 (12.0%), pericystectomy-1 (6.0%). Average estimated blood loss was 320.6 ml. Blood transfusion was performed in only 1 (4.0%) patients. Postoperative complications in the form of left-hand reactive pleuritis were marked in 3 (12.0%) cases. Average period of hospitalization amounted to 12,8В±2,2 bed-days. Echinococcectomy supplemented by cleaning of the residual cavity impulse electric discharge may be an alternative to radical methods of surgical treatment of hepatic echinococcosis, due to the fact that IED has a destructive effect against Echinococcus germinal elements, simple to use, safe.

摘要

包虫病在哈萨克斯坦是一个严重的公共卫生问题。手术治疗是肝包虫病的主要治疗方法。鉴于该病的高复发率,寻找新的手术治疗方法仍然具有现实意义。本研究的目的是提高肝包虫病手术治疗的效率和安全性;开发一种清洁残留囊腔的新物理方法。研究了脉冲电场对包虫囊肿胚层成分的实验和临床影响。为监测所开发方法的有效性,对组织学材料进行了形态学研究。实验证明,脉冲电场对包虫囊肿胚层成分的最佳作用模式是,以200毫升液体作用120秒或每1毫升体积作用0.6秒,可使其完全破坏。开发了用脉冲电场清洁残留囊腔的方法。2007年至2013年,采用该方法对25例患者进行了手术,其中男性13例(52.0%),女性12例(48.0%)。平均年龄为37.8±0.8岁。16例(64.0%)为单囊肿,9例(36.0%)为多囊肿。20例(80.0%)为原发性囊肿,5例(20.0%)为复发性囊肿。囊肿大小达10厘米的有8例(32.0%),10厘米至20厘米的有15例(60.0%),20厘米及以上的有2例(8.0%)。24.0%的病例囊肿位于肝左叶,76.0%位于右叶。76.0%的囊肿位于肝右叶,24.0%位于左叶。22例(53.0%)患者行肝包虫切除术,2例(12.0%)行切除术,1例(6.0%)行囊肿外膜切除术。平均估计失血量为320.6毫升。仅1例(4.0%)患者进行了输血。3例(12.0%)出现了以左侧反应性胸膜炎形式的术后并发症。平均住院时间为12.8±2.2天。由于脉冲电场对棘球蚴胚层成分有破坏作用、使用简单且安全,脉冲电场辅助清洁残留囊腔的肝包虫切除术可能是肝包虫病手术治疗根治方法的一种替代方法。

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