Weiss Julius H, Keel Isabelle, Immer Franz F, Wiegand Jan, Haberthür Christoph
Swisstransplant, the Swiss National Foundation for organ donation and transplantation, Bern, Switzerland.
Klinik Hirslanden, Institute of Physicians for Anaesthesia and Intensive Care, Zurich, Switzerland.
Swiss Med Wkly. 2014 Oct 23;144:w14045. doi: 10.4414/smw.2014.14045. eCollection 2014.
The Swiss Monitoring of Potential Organ Donors (SwissPOD) was initiated to investigate the causes of the overall low organ donation rate in Switzerland. The objective of our study was an assessment of the donation after brain death (DBD) process in Swiss adult intensive care units (ICUs), and to provide an overview of the donation efficiency as well as of the reasons for non-donation.
SwissPOD is a prospective cohort study of all deaths in Swiss ICUs and accident and emergency departments. This study is an analysis of SwissPOD data of all patients who deceased in an adult ICU between 1 September 2011 and 31 August 2012.
Out of 3,667 patients who died in one of the 79 adult ICUs participating in SwissPOD, 1,204 were possible, 198 potential, 133 eligible, and 94 utilised DBD donors. The consent rate was 48.0% and the conversion rate 47.5%. In 80.0% of cases, the requests for donation took place before brain death was diagnosed, resulting in a similar proportion of consents and objections as when requests were made after brain death diagnosis.
Despite the low donation rate, Swiss adult ICUs are performing well in terms of the conversion rate, similar to major European countries. The refusal rate is among the highest in Europe, which clearly has a negative impact on the donation rate. Optimising the request process seems to be the most effective means of increasing the donation rate.
瑞士启动了潜在器官捐献者监测项目(SwissPOD),以调查瑞士器官捐献率总体较低的原因。我们研究的目的是评估瑞士成人重症监护病房(ICU)中脑死亡后器官捐献(DBD)的过程,并概述捐献效率以及未进行捐献的原因。
SwissPOD是一项针对瑞士ICU以及急诊部门所有死亡病例的前瞻性队列研究。本研究分析了2011年9月1日至2012年8月31日期间在成人ICU死亡的所有患者的SwissPOD数据。
在参与SwissPOD的79个成人ICU中死亡的3667例患者中,有1204例为可能的器官捐献者,198例为潜在捐献者,133例为符合条件的捐献者,94例为实际进行了DBD器官捐献的患者。同意率为48.0%,转化率为47.5%。在80.0%的病例中,器官捐献请求在脑死亡诊断之前提出,这导致同意和反对的比例与在脑死亡诊断之后提出请求时相似。
尽管捐献率较低,但瑞士成人ICU在转化率方面表现良好,与欧洲主要国家相似。拒绝率在欧洲处于最高水平之一,这显然对捐献率产生了负面影响。优化请求流程似乎是提高捐献率的最有效手段。