抗DNA抗体的起源及意义。

The origin and significance of anti-DNA antibodies.

作者信息

Isenberg D, Shoenfeld Y

机构信息

The Bloomsbury Rheumatology Department, University College and The Middlesex Hospital Medical School, London, UK; The Department of Internal Medicine D and Research Units of Autoimmune Diseases, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.

出版信息

Immunol Today. 1987;8(9):279-82. doi: 10.1016/0167-5699(87)90189-7.

DOI:10.1016/0167-5699(87)90189-7

PMID:25344285

Abstract

Polyreactive autoantibodies able to bind double-stranded DNA are a characteristic of systemic lucus erytheamtosus. Here, David Isenberg and Yehuda Shoenfeld discuss the likelihood that DNA is the immunogen in this disorder, and review a number of cross-reactions that may underline the detection of the antibodies.

摘要

能够结合双链DNA的多反应性自身抗体是系统性红斑狼疮的一个特征。在此，大卫·伊森伯格和耶胡达·肖内菲尔德讨论了DNA作为这种疾病免疫原的可能性，并回顾了一些可能是抗体检测基础的交叉反应。