Rittig S, Knudsen U B, Jønler M, Nørgaard J P, Pedersen E B, Djurhuus J C
Institute of Experimental Clinical Research, University of Aarhus, Denmark.
Scand J Urol Nephrol Suppl. 1989;125:79-86.
In 8 adult patients with monosymptomatic nocturnal enuresis (age 18-44 years) we twice investigated the circadian rhythm of plasma vasopressin, plasma atrial natriuretic peptide, serum osmolality, serum electrolytes as well as urinary excretion in relation to urodynamic variables. Seven of the patients showed a lack of diurnal rhythmicity in plasma vasopressin at both diurnal studies with no night-time increase. The nocturnal urinary volumes exceeded the bladder capacities with an average of 155%. This was mainly caused by a large excretion of poorly concentrated urine during the first hours of sleep. Although a slight nocturnal peak in plasma atrial natriuretic peptide was found no clear pathophysiological role could be determined for this peptide. It is concluded that the previously established vasopressin production abnormality in juvenile enuresis seems to persist in adult enuretics.
在8例患有单症状性夜间遗尿症的成年患者（年龄18 - 44岁）中，我们针对血浆血管加压素、血浆心钠素、血清渗透压、血清电解质的昼夜节律以及与尿动力学变量相关的尿排泄情况进行了两次研究。在两项日间研究中，7例患者的血浆血管加压素均缺乏昼夜节律，夜间无升高。夜间尿量超过膀胱容量，平均超出155%。这主要是由于睡眠最初几小时内排出大量浓缩程度低的尿液所致。尽管发现血浆心钠素在夜间有轻微峰值，但无法确定该肽的明确病理生理作用。结论是，先前在青少年遗尿症中确定的血管加压素产生异常似乎在成年遗尿症患者中持续存在。
