基质胃泌素信号在胰腺导管腺癌发生发展及播散中的推测性作用
A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma.
作者信息
Matters Gail L, Clawson Gary A
机构信息
Department of Biochemistry and Molecular Biology, Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA.
Department of Biochemistry and Molecular Biology, Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA ; Gittlen Cancer Research Foundation and Departments of Pathology, Biochemistry and Molecular Biology, USA.
出版信息
Pancreat Disord Ther. 2013 Apr 7;Suppl 4:003. doi: 10.4172/2165-7092.S4-003.
The peptide growth factor gastrin and its receptor, the G-protein coupled cholecystokinin receptor type B (CCKR), play an integral role in the growth and progression of pancreatic ductal adenocarcinoma (PDAC). Gastrin immunoreactivity is found in the fetal pancreas but its expression is not detected in normal pancreas after birth, except when it is re-expressed in malignant lesions.
肽生长因子胃泌素及其受体——G蛋白偶联的B型胆囊收缩素受体（CCKR），在胰腺导管腺癌（PDAC）的生长和进展中发挥着不可或缺的作用。胃泌素免疫反应性在胎儿胰腺中可检测到，但出生后在正常胰腺中未检测到其表达，除非在恶性病变中重新表达。
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