人类8-氧代鸟嘌呤DNA糖基化酶hOGG1与DNA相互作用的结构特征
Structural Features of the Interaction between Human 8-Oxoguanine DNA Glycosylase hOGG1 and DNA.
作者信息
Koval V V, Knorre D G, Fedorova O S
机构信息
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave., 8, Novosibirsk, 630090, Russia ; Novosibirsk State University, Pirogova Str., 2, Novosibirsk, 630090, Russia.
出版信息
Acta Naturae. 2014 Jul;6(3):52-65.
The purpose of the present review is to summarize the data related with the structural features of interaction between the human repair enzyme 8-oxoguanine DNA glycosylase (hOGG1) and DNA. The review covers the questions concerning the role of individual amino acids of hOGG1 in the specific recognition of the oxidized DNA bases, formation of the enzyme-substrate complex, and excision of the lesion bases from DNA. Attention is also focused upon conformational changes in the enzyme active site and disruption of enzyme activity as a result of amino acid mutations. The mechanism of damaged bases release from DNA induced by hOGG1 is discussed in the context of structural dynamics.
本综述的目的是总结与人类修复酶8-氧代鸟嘌呤DNA糖基化酶（hOGG1）和DNA相互作用的结构特征相关的数据。该综述涵盖了有关hOGG1单个氨基酸在氧化DNA碱基的特异性识别、酶-底物复合物的形成以及从DNA中切除损伤碱基方面的作用的问题。还关注了酶活性位点的构象变化以及氨基酸突变导致的酶活性破坏。在结构动力学的背景下讨论了hOGG1诱导DNA释放受损碱基的机制。
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