Department of Health Sciences, IRCSS-AOU S.Martino-IST, DISSAL, Section of Dermatology, University of Genoa, Genoa, Italy.
Department of Surgical and Morphological Sciences, Anatomic Pathology Division, IRCSS-AOU S.Martino, University of Genoa, Genoa, Italy.
J Eur Acad Dermatol Venereol. 2015 Jun;29(6):1188-92. doi: 10.1111/jdv.12788. Epub 2014 Oct 28.
Granulomatous reaction is a well-known complication following soft filler procedures. However, the diagnosis of filler-induced granulomas may be challenging because of the occasional reluctance of patients to report the previously performed aesthetic procedure.
To describe a new clinical situation in which some patients, in the quest for physical perfection, become addicted to multiple sequential cosmetic injections, increasing the risk of adverse reactions.
We describe three women who developed diffuse facial nodular tumefaction after multiple procedures of filler injections into their face that occurred at different times in the previous years.
Histopathology showed a granulomatous reaction including different combined substances that were identified with different types of micro-implants in the same biopsy.
Excessive demand of multiple cosmetic injections may increase the frequency of skin granulomatous reactions and can be included in the spectrum of similar addictive dysmorphophobic behaviours. Histopathology is the best mean to achieve the diagnosis.
肉芽肿反应是软组织填充术后的一种已知并发症。然而，由于患者偶尔不愿报告之前进行的美容程序，填充物诱导的肉芽肿的诊断可能具有挑战性。
描述一种新的临床情况，即一些患者为了追求完美的身体，沉迷于多次连续的美容注射，增加了不良反应的风险。
我们描述了 3 名女性，她们在之前数年的不同时间多次进行面部填充物注射后，出现弥漫性面部结节性肿胀。
组织病理学显示肉芽肿反应，包括不同的联合物质，这些物质在同一活检中被不同类型的微型植入物所识别。
过度需求多次美容注射可能会增加皮肤肉芽肿反应的频率，并可能包含在类似成瘾性畸形恐惧症行为的范围内。组织病理学是做出诊断的最佳手段。
