Yamada Shinsuke, Inaba Masaaki
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
Clin Calcium. 2014 Nov;24(11):1605-13.
Chronic kidney disease (CKD) has a high mortality rate of cardiovascular disease (CVD) . As CKD-mineral and bone disorder (CKD-MBD) is the one of the major risk factors in CVD, it is necessary that CKD patients are controlled CKD-MBD appropriately as early as possible. However, it is difficulty that CKD-MBD condition is exactly diagnosed and controlled, because it presents various conditions according to the difference of patient's background such as having diabetes or stage of CKD. We will give an outline of the mechanism in CKD-MBD according to patient's condition and the association between CKD-MBD and vascular calcification.
慢性肾脏病(CKD)的心血管疾病(CVD)死亡率很高。由于慢性肾脏病 - 矿物质和骨代谢紊乱(CKD - MBD)是心血管疾病的主要危险因素之一,CKD患者尽早适当地控制CKD - MBD是必要的。然而,CKD - MBD的状况难以准确诊断和控制,因为它会根据患者背景的差异(如是否患有糖尿病或CKD的阶段)呈现出各种情况。我们将根据患者病情概述CKD - MBD的机制以及CKD - MBD与血管钙化之间的关联。