新型基于降冰片基体系的恶二唑硫代糖苷和无环核苷类似物的合成及其抗菌活性
Synthesis and antimicrobial activity of new norbornyl system based oxadiazole thioglycosides and acyclic nucleoside analogs.
作者信息
Mohamed Ashraf M, El-Sayed Wael A, Al-Qalawi Husam R M, Germoush Mousa O
出版信息
Acta Pol Pharm. 2014 Sep-Oct;71(5):771-80.
PMID:25362805
Abstract
New sugar hydrazones linked to norbornyl ring system, their oxadiazole acyclic nucleoside analogs and the corresponding thioglycosides were synthesized. The synthesized compounds were tested for their antimicrobial activity and displayed different degrees of activities or inhibitory actions. Their oxadiazole acyclic nucleoside analogs and thioglycosides showed higher activities.
摘要
合成了与降冰片基环系统相连的新型糖腙、它们的恶二唑无环核苷类似物以及相应的硫代糖苷。对合成的化合物进行了抗菌活性测试，结果显示出不同程度的活性或抑制作用。它们的恶二唑无环核苷类似物和硫代糖苷表现出更高的活性。
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