Ercan Cihangir Mutlu, Kayaalp Oya, Cengiz Mehmet, Keskin Ugur, Yumusak Nihat, Aydogan Umit, Ide Tayfun, Ergun Ali
Department of Obstetrics and Gynecology, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey.
Arch Gynecol Obstet. 2015 May;291(5):1103-11. doi: 10.1007/s00404-014-3524-x. Epub 2014 Nov 4.
To determine the effect of dopamine agonists in a surgically induced endometriosis model on rats.
In this prospective randomized experimental study, surgical induction of endometriosis was performed by autotransplantation technique on 52 adult female Wistar-Albino rats. Endometriosis formation was confirmed by a second-look laparotomy (n:48) 1 month later. Four study groups were randomly generated according to their treatment regimens: group 1 (leuprolide acetate, n = 12), group 2 (bromocriptine, n = 12), group 3 (cabergoline, n = 12) and group 4 (control, n = 12). Endometriotic implants were excised for histopathological examination after treatment at the setting of laparotomy. The mean surface areas and histopathological glandular tissue (GT) and stromal tissue (ST) scores of endometriotic implants were studied and compared among groups.
After 30 days of treatment, the mean surface area of the endometriotic implants of leuprolide acetate, bromocriptine and cabergoline groups was significantly decreased. The regression of endometriotic foci size in comparison to control was highest in group 1, followed by group 2, then group 3. In the histopathological evaluation both the ST and GT scores of group 1, 2 and 3 were significantly decreased in comparison to controls without a statistically significant difference between the groups.
Dopamine agonists are as effective as GnRH agonists in the regression of experimental endometriotic implants in rats. Further trials are needed to elucidate the pathways affected by dopamine agonists.
确定多巴胺激动剂对大鼠手术诱导的子宫内膜异位症模型的影响。
在这项前瞻性随机实验研究中，采用自体移植技术对52只成年雌性Wistar - 白化大鼠进行手术诱导子宫内膜异位症。1个月后通过二次剖腹探查术（n = 48）确认子宫内膜异位症形成。根据治疗方案随机分为四个研究组：第1组（醋酸亮丙瑞林，n = 12），第2组（溴隐亭，n = 12），第3组（卡麦角林，n = 12）和第4组（对照组，n = 12）。在剖腹手术时治疗后切除子宫内膜异位植入物进行组织病理学检查。研究并比较各组子宫内膜异位植入物的平均表面积以及组织病理学腺组织（GT）和基质组织（ST）评分。
治疗30天后，醋酸亮丙瑞林、溴隐亭和卡麦角林组子宫内膜异位植入物的平均表面积显著减小。与对照组相比，第1组子宫内膜异位病灶大小的消退程度最高，其次是第2组，然后是第3组。在组织病理学评估中，第1、2和3组的ST和GT评分与对照组相比均显著降低，各组之间无统计学显著差异。
多巴胺激动剂在大鼠实验性子宫内膜异位植入物消退方面与GnRH激动剂一样有效。需要进一步试验以阐明多巴胺激动剂影响的途径。
