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在阿根廷携带非洲和多伦多质粒的淋病奈瑟菌菌株中鉴定TEM-135β-内酰胺酶

Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina.

作者信息

Gianecini R, Oviedo C, Littvik A, Mendez E, Piccoli L, Montibello S, Galarza P

机构信息

Servicio de Enfermedades de Transmisión Sexual, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS Dr. Carlos G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina.

Gonococcal Antimicrobial Susceptibility Surveillance Program-Argentina (GASSP-AR), Ciudad Autónoma de Buenos Aires, Argentina.

出版信息

Antimicrob Agents Chemother. 2015 Jan;59(1):717-20. doi: 10.1128/AAC.03838-14. Epub 2014 Nov 3.

Abstract

One hundred forty-three penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates obtained in Argentina from 2008 and 2012 were examined to detect blaTEM-135 genes and to investigate plasmid profiles and multiantigen sequence types. Forty-two PPNG isolates were found to carry TEM-135, and two contained a new TEM derivative characterized as TEM-220. The blaTEM-135 allele was carried by the Toronto/Rio and African plasmids. Molecular epidemiology revealed that two blaTEM-135 isolates were related to previously described isolates from Thailand and China, indicating a common evolutionary origin.

摘要

对2008年至2012年在阿根廷获得的143株产青霉素酶淋病奈瑟菌(PPNG)分离株进行检测,以检测blaTEM-135基因,并研究质粒图谱和多抗原序列类型。发现42株PPNG分离株携带TEM-135,其中两株含有一种新的TEM衍生物,被鉴定为TEM-220。blaTEM-135等位基因由多伦多/里约热内卢质粒和非洲质粒携带。分子流行病学研究表明,两株携带blaTEM-135的分离株与先前描述的来自泰国和中国的分离株有关,表明它们有共同的进化起源。

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