Akoh Jacob A, Rana Tahawar A, Higgs Daniel
South West Transplant Centre Gastroenterology, Surgery & Renal Services Directorate, Plymouth Hospitals NHS Trust, Derriford Hospital, Plymouth PL6 8DH, UK.
Surg Res Pract. 2014;2014:678979. doi: 10.1155/2014/678979. Epub 2014 Jan 2.
Background. The challenge in managing patients undergoing renal transplantation is how to achieve optimum levels of anticoagulation to avoid both clotting and postoperative bleeding. We report a rare case of severe postoperative retroperitoneal bleeding including psoas haematomata complicating renal transplantation. Case Report. SM, a 55-year-old female, had a past history of aortic valve replacement, cerebrovascular event, and thoracic aortic aneurysm and was on long-term warfarin that was switched to enoxaparin 60 mg daily a week prior to her living donor transplantation. Postoperatively, she was started on a heparin infusion, but this was complicated by a large retroperitoneal bleed requiring surgical evacuation on the first postoperative day. Four weeks later, she developed features compatible with acute femoral neuropathy and a CT scan revealed bilateral psoas haematomata. Following conservative management, she made steady progress and was discharged home via a community hospital 94 days after transplantation. At her last visit 18 months after transplantation, she had returned to full fitness with excellent transplant function. Conclusion. Patients in established renal failure who require significant anticoagulation are at increased risk of bleeding that may involve prolonged hospitalisation and more protracted recovery and patients should be carefully counselled about this.
背景。管理接受肾移植的患者面临的挑战是如何实现最佳抗凝水平,以避免凝血和术后出血。我们报告了一例罕见的肾移植术后严重腹膜后出血病例,包括腰大肌血肿。病例报告。SM,一名55岁女性,有主动脉瓣置换术、脑血管事件和胸主动脉瘤病史,长期服用华法林,在活体供肾移植前一周改为每日皮下注射依诺肝素60mg。术后,她开始接受肝素输注,但术后第一天因大量腹膜后出血而需要手术引流,情况变得复杂。四周后,她出现了与急性股神经病变相符的症状,CT扫描显示双侧腰大肌血肿。经过保守治疗,她恢复顺利,移植后94天通过社区医院出院回家。在移植后18个月的最后一次随访中,她已完全康复,移植肾功能良好。结论。需要大量抗凝治疗的终末期肾衰竭患者出血风险增加,可能需要延长住院时间和更长的康复时间,应就此对患者进行仔细的咨询。