反复静脉注射葡聚糖（水溶性大分子）对大鼠的影响。

Effects of Repeated Intravenous Administration of Dextrans,Water-soluble Macromolecules, in Rats.

作者信息

Kitazawa Ikue, Ito Shino, Kagawa Yusuke, Suehiro-Narita Miki, Hashizume Naoto, Minamisawa Yuka, Nii Aisuke, Kawakami Akio, Nakajima Shinichi

机构信息

Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.

出版信息

J Toxicol Pathol. 2014 Oct;27(3-4):231-4. doi: 10.1293/tox.2013-0067. Epub 2014 Jun 9.

DOI:10.1293/tox.2013-0067

PMID:25378808

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4217235/

Abstract

We investigated the influence of repeated intravenous administration of dextrans (DEXs) to rats. Seven-week-old Sprague Dawley rats (6 males/group) were given intravenously 10% saline solutions of dextrans (DEXs), 40 kDa or 200-300 kDa, at a dose level of 5 mL/kg/day for 28 days and they were examined histopathologically. Another group (3 males/group) was administered saline in a similar manner and served as the control. Histopathological changes indicating accumulation of DEXs in the mononuclear phagocyte system (MPS) and the liver were noted in the treated groups. The incidence and severity of the findings were molecular weight-dependent, except for the lungs. These results are considered useful in interpreting data from preclinical studies, in which DEXs or their derivatives are administered as test or control substances.

摘要

我们研究了对大鼠反复静脉注射右旋糖酐（DEXs）的影响。将7周龄的斯普拉格-道利大鼠（每组6只雄性）静脉注射40 kDa或200 - 300 kDa的右旋糖酐（DEXs）的10%盐溶液，剂量为5 mL/kg/天，持续28天，然后对它们进行组织病理学检查。另一组（每组3只雄性）以类似方式给予生理盐水作为对照。在治疗组中观察到表明DEXs在单核吞噬细胞系统（MPS）和肝脏中蓄积的组织病理学变化。除肺部外，这些发现的发生率和严重程度与分子量有关。这些结果被认为有助于解释临床前研究的数据，在这些研究中，DEXs或其衍生物作为测试或对照物质给药。