Dai Yun-Jian, Xu Zheng-Hao, Feng Bo, Xu Ceng-Lin, Zhao Hua-Wei, Wu Deng-Chang, Hu Wei-Wei, Chen Zhong
Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Basic Medical College, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Department of Neurology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Neurosci Bull. 2014 Dec;30(6):913-922. doi: 10.1007/s12264-014-1482-8. Epub 2014 Nov 13.
Gender differences are involved in many neurological disorders including epilepsy. However, little is known about the effect of gender difference on the risk of epilepsy in adults with a specific early pathological state such as complex febrile seizures (FSs) in infancy. Here we used a well-established complex FS model in rats and showed that: (1) the susceptibility to seizures induced by hyperthermia, pentylenetetrazol (PTZ), and maximal electroshock (MES) was similar in male and female rat pups, while males were more susceptible to PTZ- and MES-induced seizures than age-matched females in normal adult rats; (2) adult rats with complex FSs in infancy acquired higher seizure susceptibility than normal rats; importantly, female FS rats were more susceptible to PTZ and MES than male FS rats; and (3) the protein expression of interleukin-1β, an inflammatory factor associated with seizure susceptibility, was higher in adult FS females than in males, which may reflect a gender-difference phenomenon of seizure susceptibility. Our results provide direct evidence that the acquired seizure susceptibility after complex FSs is gender-dependent.
性别差异与包括癫痫在内的许多神经系统疾病有关。然而，对于性别差异对患有特定早期病理状态（如婴儿期复杂性热性惊厥（FSs））的成年人癫痫风险的影响知之甚少。在这里，我们使用了一种成熟的大鼠复杂性FS模型，并表明：（1）雄性和雌性幼鼠对热疗、戊四氮（PTZ）和最大电休克（MES）诱导的癫痫发作的易感性相似，而在正常成年大鼠中，雄性比年龄匹配的雌性更容易受到PTZ和MES诱导的癫痫发作的影响；（2）婴儿期患有复杂性FSs的成年大鼠比正常大鼠获得更高的癫痫发作易感性；重要的是，雌性FS大鼠比雄性FS大鼠更容易受到PTZ和MES的影响；（3）与癫痫发作易感性相关的炎症因子白细胞介素-1β在成年FS雌性大鼠中的蛋白表达高于雄性，这可能反映了癫痫发作易感性的性别差异现象。我们的结果提供了直接证据，表明复杂性FSs后获得的癫痫发作易感性是性别依赖性的。
