撤回：高加索人群中ACE I/D基因多态性与2型糖尿病肾病易感性及2型糖尿病发展为2型糖尿病肾病风险的关联
Retracted: Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population.
作者信息
Liu Guohui, Zhou Tian-Biao, Jiang Zongpei, Zheng Dongwen
机构信息
Department of Nephrology, Dong Guan Municipal People's Hospital, Dongguan, China.
Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China.
出版信息
J Renin Angiotensin Aldosterone Syst. 2015 Mar;16(1):165-71. doi: 10.1177/1470320314557849. Epub 2014 Nov 14.
BACKGROUND AND OBJECTIVE
The association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with type-2 diabetic nephropathy (T2DN) susceptibility and the risk of type-2 diabetes mellitus (T2DM) developing into T2DN in Caucasian populations is still controversial. A meta-analysis was performed to evaluate the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations.
METHOD
A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases.
RESULTS
Sixteen articles were identified for the analysis of the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations. ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. Sensitivity analysis according to sample size of case (<100 vs. ≥100) was also performed, and the results were similar to the non-sensitivity analysis.
CONCLUSIONS
ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. However, more studies should be performed in the future.
背景与目的
在白种人群中，血管紧张素转换酶（ACE）插入/缺失（I/D）基因多态性与2型糖尿病肾病（T2DN）易感性以及2型糖尿病（T2DM）发展为T2DN的风险之间的关联仍存在争议。进行了一项荟萃分析，以评估ACE I/D基因多态性与白种人群中T2DN易感性以及T2DM发展为T2DN的风险之间的关联。
方法
进行了预定义的文献检索并选择符合条件的相关研究，以从电子数据库中收集数据。
结果
确定了16篇文章，用于分析ACE I/D基因多态性与白种人群中T2DN易感性以及T2DM发展为T2DN的风险之间的关联。ACE I/D基因多态性与白种人群中T2DN易感性以及T2DM患者发生T2DN的风险无关。还根据病例样本量（<100与≥100）进行了敏感性分析，结果与非敏感性分析相似。
结论
在白种人群中，ACE I/D基因多态性与T2DN易感性以及T2DM患者发生T2DN的风险无关。然而，未来应开展更多研究。
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