全基因组扫描显示男性性取向存在显著连锁。
Genome-wide scan demonstrates significant linkage for male sexual orientation.
作者信息
Sanders A R, Martin E R, Beecham G W, Guo S, Dawood K, Rieger G, Badner J A, Gershon E S, Krishnappa R S, Kolundzija A B, Duan J, Gejman P V, Bailey J M
机构信息
Department of Psychiatry and Behavioral Sciences,NorthShore University HealthSystem Research Institute,Evanston,IL,USA.
Department of Human Genetics,University of Miami,Miami,FL,USA.
出版信息
Psychol Med. 2015 May;45(7):1379-88. doi: 10.1017/S0033291714002451. Epub 2014 Nov 17.
BACKGROUND
Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28.
METHOD
We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date.
RESULTS
We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research.
CONCLUSIONS
Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.
背景
家族研究和双胞胎研究的结果支持基因对男性性取向发展的影响。然而，先前的研究在与Xq28染色体的连锁关系上得出了相互矛盾的证据。
方法
我们对409对同性恋兄弟（来自384个家庭的908名被分析个体）进行了全基因组连锁扫描，这是迄今为止同类研究中规模最大的一项。
结果
我们确定了两个连锁区域：8号染色体的着丝粒周围区域（最大两点对数优势比=4.08，最大多点对数优势比=2.59），该区域与先前对155对兄弟进行的单独连锁扫描中第二强的区域重叠；以及Xq28（最大两点对数优势比=2.99，最大多点对数优势比=2.76），先前的研究也涉及到该区域。
结论
研究结果，尤其是结合过去的研究来看，支持在8号染色体着丝粒周围区域和Xq28染色体上存在影响男性性取向发展的基因。
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