N-乙酰吲哚酚的一种简单且稳定的制备方法：用于产靛基质底物的前体。

A simple and robust preparation of N-acetylindoxyls: precursors for indigogenic substrates.

作者信息

Gandy Michael N, Byrne Lindsay T, Stubbs Keith A

机构信息

School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia.

出版信息

Org Biomol Chem. 2015 Jan 21;13(3):905-8. doi: 10.1039/c4ob02248c.

DOI:10.1039/c4ob02248c

PMID:25407923

Abstract

A generalised, simple and efficient synthesis of N-acetyl-5-bromo-4-chloroindoxyl and related analogues required for the synthesis of indigogenic substrates to probe for biological activities is reported. The method is both synthetically and operationally simple and represents a significant improvement on existing methods.

摘要

报道了一种用于合成用于探测生物活性的靛原底物所需的N-乙酰基-5-溴-4-氯吲哚酚及其相关类似物的通用、简单且高效的合成方法。该方法在合成和操作上都很简单，是对现有方法的重大改进。