TOMBU和COMBU作为源自Oxyma-B的新型鎓盐型肽偶联试剂。

TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B.

作者信息

Jad Yahya E, Khattab Sherine N, de la Torre Beatriz G, Govender Thavendran, Kruger Hendrik G, El-Faham Ayman, Albericio Fernando

机构信息

Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban 4001, South Africa.

Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt.

出版信息

Molecules. 2014 Nov 18;19(11):18953-65. doi: 10.3390/molecules191118953.

DOI:10.3390/molecules191118953

PMID:25412042

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6271478/

Abstract

Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal that they show better performance than HBTU in terms of preserving chiral integrity and coupling yields, but slightly worse performance than COMU.

摘要

在此，我们描述了两种新型鎓盐TOMBU和COMBU，它们衍生自最近报道的用于肽键合成的Oxyma-B。这些偶联试剂在N，N-二甲基甲酰胺（DMF）中比COMU更稳定。此外，通过在溶液和固相合成中使用各种肽合成模型，我们发现它们在保持手性完整性和偶联产率方面表现优于HBTU，但性能略逊于COMU。