Jad Yahya E, Khattab Sherine N, de la Torre Beatriz G, Govender Thavendran, Kruger Hendrik G, El-Faham Ayman, Albericio Fernando
Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban 4001, South Africa.
Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt.
Molecules. 2014 Nov 18;19(11):18953-65. doi: 10.3390/molecules191118953.
Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal that they show better performance than HBTU in terms of preserving chiral integrity and coupling yields, but slightly worse performance than COMU.
在此，我们描述了两种新型鎓盐TOMBU和COMBU，它们衍生自最近报道的用于肽键合成的Oxyma-B。这些偶联试剂在N，N-二甲基甲酰胺（DMF）中比COMU更稳定。此外，通过在溶液和固相合成中使用各种肽合成模型，我们发现它们在保持手性完整性和偶联产率方面表现优于HBTU，但性能略逊于COMU。
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