Parkes Jeannette, Hendricks Marc, Ssenyonga Peter, Mugamba John, Molyneux Elizabeth, Schouten-van Meeteren Antoinette, Qaddoumi Ibrahim, Fieggen Graham, Luna-Fineman Sandra, Howard Scott, Mitra Dipayan, Bouffet Eric, Davidson Alan, Bailey Simon
Department of Radiation Oncology, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.
Pediatr Blood Cancer. 2015 Apr;62(4):553-64. doi: 10.1002/pbc.25313. Epub 2014 Nov 21.
Effective treatment of children with medulloblastoma requires a functioning multi-disciplinary team with adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities and personnel. In addition the treating centre should have the capacity to effectively screen and manage any tumour and treatment-associated complications. These requirements have made it difficult for many low and middle-income countries (LMIC) centres to offer curative treatment. This article provides management recommendations for children with standard-risk medulloblastoma (localised tumours in children over the age of 3-5 years) according to the level of facilities available.
有效治疗髓母细胞瘤患儿需要一个运作良好的多学科团队,配备足够的神经外科、神经放射学、病理学、放疗和化疗设施及人员。此外,治疗中心应具备有效筛查和处理任何肿瘤及治疗相关并发症的能力。这些要求使得许多低收入和中等收入国家(LMIC)的中心难以提供根治性治疗。本文根据现有设施水平,为标准风险髓母细胞瘤患儿(3至5岁以上儿童的局限性肿瘤)提供管理建议。