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在心胸重症监护病房早期使用双水平气道正压通气(BiPAP)能否预防再次插管?

Does early use of bilevel positive airway pressure (bipap) in cardiothoracic intensive care unit prevent reintubation?

作者信息

Sağıroğlu G, Baysal A, Copuroğlu E, Gül Yg, Karamustafaoğlu Ya, Dogukan M

机构信息

Department of Anesthesiology and Reanimation, Trakya University Edirne, Turkey.

Anesthesiology and Reanimation Clinic, Kartal Kosuyolu High Speciality Research and Training Hospital Istanbul, Turkey.

出版信息

Int J Clin Exp Med. 2014 Oct 15;7(10):3439-46. eCollection 2014.

Abstract

INTRODUCTION

Non-invasive ventilation (NIV) is a preferred treatment in acute respiratory failure after operations. Our aim is to investigate the success of early use of bilevel positive airway pressure (BIPAP) after cardiac or thoracic surgeries to prevent reintubation.

METHODS

In a prospective randomized study, 254 patients were divided into two groups depending on the time period between extubation and the application of BIPAP. In Group 1 BIPAP was applied after extubation within 48 hours after surgery following fulfilling of acute respiratory failure criterias whereas, in Group 2, BIPAP was applied one hour after extubation for two episodes of 20 minute duration and 3 hours apart. Arterial blood gas values (pH, PaO2, PaCO2) at first and fourth hour after BIPAP were collected.

RESULTS

In comparison between groups, no significant differences were observed for arterial blood gas values of pH and PaCO2 at baseline, one and four hours after BIPAP (p > 0.05) however, the PaO2 values at one and four hours after BIPAP were significantly better in Group 1 in comparison to Group 2 (p < 0.001, p < 0.001; respectively). Reintubation rate was 14 patients (11%) in Group 1 and 7 patients (5.5%) in Group 2 (p = 0.103).

CONCLUSIONS

The early and prophylactic use of BIPAP after cardiac or thoracic operations did not provide diminished rates in the postoperative complications such as reintubation.

摘要

引言

无创通气(NIV)是术后急性呼吸衰竭的首选治疗方法。我们的目的是研究在心脏或胸科手术后早期使用双水平气道正压通气(BIPAP)预防再次插管的成功率。

方法

在一项前瞻性随机研究中,根据拔管与应用BIPAP之间的时间段将254例患者分为两组。在第1组中,在术后48小时内拔管后,在满足急性呼吸衰竭标准后应用BIPAP;而在第2组中,拔管后1小时应用BIPAP,持续20分钟,共2次,间隔3小时。收集BIPAP应用后第1小时和第4小时的动脉血气值(pH、PaO2、PaCO2)。

结果

两组比较,BIPAP应用前、应用后1小时和4小时的pH和PaCO2动脉血气值无显著差异(p>0.05),但与第2组相比,第1组BIPAP应用后1小时和4小时的PaO2值明显更好(分别为p<0.001,p<0.001)。第1组再次插管率为14例(11%),第2组为7例(5.5%)(p=0.103)。

结论

心脏或胸科手术后早期预防性使用BIPAP并不能降低再次插管等术后并发症的发生率。

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