老年人放疗增强的耳毒性
Radiotherapy-enhanced ototoxicity in elderly.
作者信息
Malgonde Monika S, Kumar Manoj
机构信息
Department of Ear, Nose and Throat, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, India.
Department of Orthopaedics, Lilavati Hospital and Research Centre, Bandra, Mumbai, Maharashtra, India.
出版信息
South Asian J Cancer. 2014 Oct;3(4):221-2. doi: 10.4103/2278-330X.142982.
INTRODUCTION
Most head and neck cancers occur in elderly age and there is a natural occurrence of sensorineural hearing loss (SNHL) due to age also. Despite the ages and the physiological changes inherent to ageing, their auditory systems when exposed to aggressive agents caused the hearing loss to be greater as a consequence of the treatment received.
MATERIALS AND METHODS
Histopathologically proved 66 head and neck cancer patients were subjected to radiotherapy (RT) and 34 patients were subjected to concomitant chemoradiation (RT + CT) to study the occurrence of SNHL from 1(st) September 2010 to 31(st) August 2012.
RESULT
It was found that the percentage of significant SNHL was more in patients >50 years after RT and RT + CT. It was also found that the results were significant.
CONCLUSION
The occurrence of SNHL is more in elderly and the concern for the quality of life of patients undergoing cancer treatment is necessarily growing. Hence, the determination of hearing loss should be a part of investigations to enable better rehabilitation in elderly.
引言
大多数头颈癌发生于老年人群，并且由于年龄因素自然会出现感音神经性听力损失（SNHL）。尽管存在年龄以及衰老所固有的生理变化，但他们的听觉系统在接触侵袭性因素时，由于接受的治疗而导致听力损失更大。
材料与方法
对66例经组织病理学证实的头颈癌患者进行放射治疗（RT），对34例患者进行同步放化疗（RT + CT），以研究2010年9月1日至2012年8月31日期间SNHL的发生情况。
结果
发现年龄>50岁的患者在接受RT和RT + CT后出现显著SNHL的百分比更高。还发现结果具有显著性。
结论
SNHL在老年人中更为常见，对癌症治疗患者生活质量的关注必然日益增加。因此，听力损失的测定应成为检查的一部分，以便能更好地对老年人进行康复治疗。
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