Wang Ji, Liu Shujun, Li Hongyu, Sun Jing, Zhang Sijin, Xu Xiaohong, Liu Yingying, Wang Yangwei, Miao Lining
Department of Nephrology, Second Hospital of Jilin University, Ziqiang Street 218, Nanguan District, Changchun, China.
Int Urol Nephrol. 2015 Jan;47(1):209-15. doi: 10.1007/s11255-014-0829-4. Epub 2014 Nov 26.
This article reviews the available rodent models of peritoneal dialysis (PD) that have been developed over the past 20 years and the complications associated with their use. Although there are several methods used in different studies, the focus of this article is not to review or provide detailed summaries of these methods. Rather, this article reviews the most common methods of establishing a dialysis model in rodents, the assays used to observe function of the peritoneum in dialysis, and how these models are adapted to study peritonitis and peritoneal fibrosis. We compared the advantages and disadvantages of different methods, which should be helpful in studies of PD and may provide valuable data for further clinical studies.
本文回顾了过去20年中已开发的腹膜透析(PD)啮齿动物模型以及与使用这些模型相关的并发症。尽管不同研究中使用了多种方法,但本文的重点不是回顾或详细总结这些方法。相反,本文回顾了在啮齿动物中建立透析模型的最常用方法、用于观察透析中腹膜功能的检测方法,以及这些模型如何用于研究腹膜炎和腹膜纤维化。我们比较了不同方法的优缺点,这对腹膜透析研究应有所帮助,并可能为进一步的临床研究提供有价值的数据。