Li Dan, Zhou Minwen, Peng Xiaoyan, Sun Huiyu
Department of Ophthalmology, Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China.
BMC Ophthalmol. 2014 Nov 27;14:147. doi: 10.1186/1471-2415-14-147.
To evaluate the role of plasma total homocysteine (tHcy) and homozygosity for the thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype in the risk of retinal vein occlusion (RVO).
Relevant studies were selected through an extensive search of PubMed, EMBASE, and the Web of Science databases. Summary weighted mean differences (WMDs) or odds ratios (ORs) and 95% confidence intervals (CI) were calculated with a random-effects model.
Forty-two studies with 6445 participants were included in this updated systematic review and meta-analysis. The mean plasma tHcy level in the RVO patients was significantly higher than in the controls (WMD =2.13 μmol/L; 95% CI: 1.29 to 2.98, P < 0.001), but there was evidence of between-study heterogeneity (P < 0.001). No significant association between MTHFR C677T genotype and RVO was found under all genetic models.
There was some evidence that plasma tHcy is associated with an increased risk of RVO. There was no evidence to suggest an association between homozygosity for the MTHFR C677T genotype and RVO.
评估血浆总同型半胱氨酸（tHcy）以及亚甲基四氢叶酸还原酶（MTHFR）C677T基因型热不稳定变异体的纯合性在视网膜静脉阻塞（RVO）风险中的作用。
通过广泛检索PubMed、EMBASE和科学网数据库筛选相关研究。采用随机效应模型计算汇总加权平均差（WMDs）或比值比（ORs）及95%置信区间（CI）。
本更新的系统评价和荟萃分析纳入了42项研究，共6445名参与者。RVO患者的血浆tHcy平均水平显著高于对照组（WMD =2.13 μmol/L；95% CI：1.29至2.98，P < 0.001），但有研究间异质性的证据（P < 0.001）。在所有遗传模型下，未发现MTHFR C677T基因型与RVO之间存在显著关联。
有证据表明血浆tHcy与RVO风险增加有关。没有证据表明MTHFR C677T基因型纯合性与RVO之间存在关联。
