癌症中Wnt信号通路的表观遗传改变：一篇综述
Epigenetic alterations of the Wnt signaling pathway in cancer: a mini review.
作者信息
Serman Ljiljana, Nikuseva Martic Tamara, Serman Alan, Vranic Semir
机构信息
Department of Biology, School of Medicine, University of Zagreb.
出版信息
Bosn J Basic Med Sci. 2014 Nov 12;14(4):191-4. doi: 10.17305/bjbms.2014.4.205.
Abstract
Epigenetic mechanisms play a crucial role in cellular proliferation, migration and differentiation in both normal and neoplastic development. One of the key signaling pathways whose components are altered through the epigenetic mechanisms is the Wnt signaling pathway. In this review, we briefly discuss the key concepts of epigenetics and focus on the recent advances in the Wnt signaling pathway research and its potential diagnostic and therapeutic implications.
摘要
表观遗传机制在正常和肿瘤发育过程中的细胞增殖、迁移及分化中发挥着关键作用。其组成部分通过表观遗传机制发生改变的关键信号通路之一是Wnt信号通路。在本综述中，我们简要讨论表观遗传学的关键概念，并重点关注Wnt信号通路研究的最新进展及其潜在的诊断和治疗意义。
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