Mishell D R
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
Postgrad Med. 1989 Apr;Spec No:84-8; discussion 89-90.
The question that still remains today is, What is an ideal formulation for administering estrogens? There have been no large-scale, long term studies to answer this question. But the pendulum appears to be swinging from cyclic combination therapy, or sequential combination therapy, to continuous therapy. There is less bleeding and compliance is better. There is no difference in the effects on lipids, and it looks as though the endometrium maintains its atrophy. The future in developing the ideal formulation may lie in this direction; however, more studies need to be coordinated and done in several centers.
