Kakizaki H, Matsumoto K
Dept. of Orthopedic Surgery, Hirosaki University School of Medicine.
Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-3):1827-33.
Since 1981, 37 cases of soft tissue sarcomas have been treated in our clinic. There were 20 males and 17 females with an average age of 43.5 years old. Histopathological classifications were liposarcomas 9 cases, MFH 8 cases, synovial sarcoma 5 cases, rhabdomyosarcoma 3 cases etc. Twenty-four cases (65%) were located in lower extremity, 11 cases (30%) in upper extremity, and 2 cases (5%) in trunk. All cases were treated with surgical intervention. Postoperative radiation was undertaken in 4 cases and adjuvant chemotherapy in 12 cases, respectively. There were 28 cases (76%) of excisional surgery; i.e., so-called limb salvage operation, and 9 cases (24%) of amputation or disarticulation. In August 1987, 10 cases had died of disease (DOD) and 27 cases were alive, but 4 cases were alive with disease (AWD). Each of the DOD and AWD cases were in stage III (by Enneking's surgical staging system) at first arrival to our clinic, or multioperated cases or cases with rapid distant metastases soon after operation. In conclusion, it was emphasized that in order to improve the clinical results, the soft tissue sarcomas must be treated earlier and that more effective chemotherapeutical protocols should be developed in the future.
自1981年以来,我院共治疗软组织肉瘤37例。其中男性20例,女性17例,平均年龄43.5岁。组织病理学分类包括脂肪肉瘤9例、恶性纤维组织细胞瘤8例、滑膜肉瘤5例、横纹肌肉瘤3例等。24例(65%)位于下肢,11例(30%)位于上肢,2例(5%)位于躯干。所有病例均接受手术治疗。术后分别有4例接受放疗,12例接受辅助化疗。有28例(76%)行切除手术,即所谓的保肢手术,9例(24%)行截肢或关节离断术。1987年8月,10例患者死于疾病(DOD),27例存活,但4例带瘤存活(AWD)。DOD和AWD病例在初诊我院时均为Ⅲ期(根据Enneking手术分期系统),或为多次手术病例或术后很快出现远处转移的病例。总之,强调为了提高临床疗效,软组织肉瘤必须早期治疗,并且未来应制定更有效的化疗方案。